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  4. 陳嘉祥 (Chia-Hsiang Chen)

陳嘉祥 (Chia-Hsiang Chen)

陳嘉祥 (Chia-Hsiang Chen)

Position

Professor

Education

Ph.D. in Biomedicine, City University of New York

E-mail

cchen3801@mail.cgu.edu.tw

Office Tel

+886-3-211-8800 ext.3812

Fax

+886-3-211-8700

Laboratory

分子與轉譯精神醫學研究室

Spciality

Genetic etiology of major psychiatric disorders

Lab & Research Interest

Dr. Chen’s primary interest is to search for the genetic etiology of major psychiatric disorders such as schizophrenia, autism, mental retardation, and drug addiction. He uses systematic genetic approaches including karyotyping, array-based comparative genomic hybridization, fluorescence in situ hybridization, real-time quantitative PCR, re-sequencing, genotyping, next generation sequencing combined with case-control study design and family study to uncover the genetic underpinnings of psychiatric disorders. He also conducts in vitro and in vivo assays to characterize the functional significance of mutations associated with psychiatric disorders to understand the pathogenesis of psychiatric disorders. His long-term goal is to invent new medicine and new way to improve the treatment of patients who suffer from mental illnesses.

Publications

Publication:

  1. Li JM, Lu CL, Cheng MC, Luu SU, Hsu SH, Chen CH*. Genetic analysis of the DLGAP1 gene as a candidate gene for schizophrenia. Psychiatr Res 2013 Jan 30;205(1-2):13-7.
  2. Lee CP, Chu CL, Liu CY, Chen CH*. Neuropsychiatric complications in a patient with Marfan syndrome. Acta Neuropsychiatrica 2013; 25 (4):243-247.
  3. Chen YH, Chen CH*. The development of antibody-based immunotherapy for methamphetamine abuse: immunization, and virus-mediated gene transfer approaches. Curr Gene Ther 2013; Feb;13:39-50.
  4. Chen YH, Liao DL, Cheng MC, Lai CH, Chen CH*. Genetic and expressive analyses of AUTS2 as a susceptibility gene of heroin dependence. Drug Alcohol Depend 2013;128:238-42.
  5. Li JM, Lu CL, Cheng MC, Luu SU, Hsu SH, Chen CH*. Exonic resequencing of the DLGAP3 gene as a candidate gene for schizophrenia. Psychiatr Res 2013; 208(1):84-7.
  6. Chao YL, Chen CH. An introduction to microRNAs and their dysregulation in psychiatric disorders. Tzu Chi Med J 2013;25:1-7.
  7. Lin PI, Kuo PS, Chen CH, Wu JY, Gau SSF, Wu YY, Liu SK. Runs of homozygosity associated with speech delay in autism in a Taiwanese Han population: evidence for the recessive model. PLoS One 2013, 8(8):e72056.
  8. Liao HM, Gau SSS, Tsai WC, Fang JS, Su YC, Chou MC, Liu SK, Chou WJ, Wu YY, Chen CH*. Chromosomal abnormalities in patients with autism spectrum disorders from Taiwan. Am J Med Genet B Neuropsychiatr Genet 2013 Oct;162(7):734-41.
  9. Chien WH, Gau SSF, Lai CH, Chen CH, Tsai WH, Wu YY, Chen PH, Shang CY, Chen CH*.. Increased gene expression of FOPX1 is associated with autism spectrum disorders. Mol Autism 2013 Jul 1;4(1):23.
  10. Chien WH, Gau SSS, Liao HM, Chiu YN, Wu YY, Shang CY, Tsai WC, Tsai HM, Chen CH*. Deep exonic resequencing of DLGAP2 as a candidate gene of autism. Mol Autism 2013 Aug 1;4(1):26.
  11. Chen YH, Huang YS, Chen CH*. Increased plasma level of tumor necrosis factor-alpha (TNF-) in patients with narcolepsy in Taiwan. Sleep Med 2013 Dec;14(12):1272-6.
  12. Chen YH, Huang YS, Chien WH, Chen CH*. Association analysis of HLA-DQB1 gene with narcolepsy in Han Chinese patients from Taiwan. Sleep Med 2013 Dec;14(12):1393-7.
  13. Liao DL, Chen PC, Chen CH, Hsieh CJ, Huang YF, Shih WI, Cheng JJS. Higher methadone doses are associated with lower mortality in patients of opioid dependence in Taiwan. J Psychiatr Res 2013 Oct;47(10):1530-4.
  14. Wu KY, Chang CM, Liang HY, Wu CS, Chia-Hsuan Wu E, Chen CH, Chau YL, Tsai HJ. Increased risk of developing dementia in patients with bipolar disorder: a nested matched case-control study. Bipolar Disord 2013 Nov;15(7):787-94.
  15. Liao DL, Cheng MC, Hsu SH, Lai CH, Tsai HJ, Chen CH*. Comparative gene expression profiling analysis of lymphoblastoid cells reveals neuron-specific enolase gene (ENO2) as a susceptibility gene of heroin dependence. Addict Biol 2014 Jan 19(1):102-10.
  16. Huang YS, Guilleminault C, Chen CH, Lai PC, Hwang FM. Narcolepsy-cataplexy and schizophrenia in adolescents. Sleep Med 2014 Jan;15(1):15-22.
  17. Li JM, Lu CL, Cheng MC, Luu SU, Shu SH, Hu TM, Tsia HY, Chen CH*. Role of the DLGAP2 gene encoding the SAP90/PSD-95-associated protein 2 in schizophrenia. PLoS One 2014 Jan 8;9(1):e85373.
  18. Hsu YC, Chen SL, Wang YJ, Chen YH, Wang DY, Chen L, Chen CH, Chen HH, Chiu IM. Signaling adaptor protein SH2B1 enhances neurite outgrowth and accelerates the maturation of human induced neurons. Stem Cells Transl Med 2014 Jun;3(6):713-22.
  19. Huang CC, Cheng MC, Tsai HM, Lai CH, Chen CH*. Genetic analysis of GABRB3 at 15q12 as a candidate gene of schizophrenia. Psychiatr Genet 2014 Aug;24(4):151-7.
  20. Wu KY, Hsiao IT, Chen CS, Chen CH, Hsieh CJ, Wai YY, Chang CJ, Tseng HJ, Yen TC, Liu CY, Lin KJ. Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography. Eur J Nucl Med Mol Imaging 2014; 41:714–722.
  21. Jiang-Xie LF, Liao HM, Chen CH, Chen YT, Ho SY, Lu DH, Lee LJ, Liou HH, Fu WM, Gau SSF, Lu DH. Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits. Mol Autism 2014; 5:32. (Co-first author)
  22. Chen CH, Huang CC, Cheng MC, Chiu YN, Tsai WC, Liu SK, Wu YY, Tsai HM, Gau SSS*. Genetic analysis of GABRB3 as a candidate gene of autism spectrum disorders. Mol Autism 2014 Jun 25;5:36.
  23. Chen CH*, Huang CC, Liao DL. Association of GABRB3 promoter variants with heroin dependence. PLoS One 2014 Jul 15;9(7):e102227.