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鄭美玲(Mei-Ling Cheng)

Mei-Ling Cheng




Department of Biochemistry, National Taiwan University, Taiwan



Office Tel

+886-3-211-8800 ext.3811

Lab Tel

+886-3-211-8800 ext.3650






Metabolism, Free redical biomedical science and translational medicine

Lab & Research Interest

  1. Oxidative stress and cell metabolism
  2. Study the role of oxidative stress on degenerative diseases
  3. LC/MS-based Metabolomic approach for degenerative disease study



1. Cheng ML,Weng SF, Kuo CH, Ho HY. (2014.11)Enterovirus 71 Induces Mitochondrial Reactive OxygenSpecies Generation That is Required for EfficientReplication. PLoS One9(11):e113234(SCI IF=3.534)

2. Ho HY, Cheng ML*, Chiu DT. (2014.9) Glucose-6-phosphate dehydrogenase--beyond the realm of red cell biology.Free Radical Research 48(9):1028-48 (SCI IF=2.989)(*Co-first author paper)

3. Chow SE, Kao CH, Liu YT, Cheng ML, Yang YW, Huang YK, Hsu CC, Wang JS.(2014) Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells. Apoptosis. 19(3):527-41 (SCI IF=3.614)

4. Cheng ML, Ho HY, Lin HY, Lai YC, Chiu DTY (2013) Effective NET Formation in Neutrophils from Individuals with G6PD Taiwan-Hakka is Associated with Enhanced NADP+ Biosynthesis Free Radical Research47: 699-709  (SCI IF=2.989)

5. Lin HR, Wu CC, Wu YH, Hsu CW, Cheng ML#, Chiu DTY (2013) Proteome-wide dysregulation by G6PD reveals a novel protective role for G6PD in aflatoxin B1-mediated cytotoxicity.  Journal of proteome research12:3434-48(SCI IF=5.001)  ( #Co-corresponding)

6. Huang CF, Cheng ML, Fan CM, Hong CY, Shiao MS (2013.6) Nicotinuric Acid: A Potential Marker of Metabolic Syndrome through a Metabolomics-Based Approach. Diabetes Care 36(6):1729-1731 (SCI IF=8.570)

7. Wu TC, Chen HT, Chang HY, Yang CY, Hsiao MC, Cheng ML, Chen JC. (2013.6) Mineralocorticoid receptor antagonist spironolactone prevents chronic corticosterone induced depression-like behavior. Psychoneuroendocrinology38(6):871-883 (SCI IF=5.591)

8. Yang HC, Chen TL, Wu YH, Cheng KP, Lin YH, Cheng ML, Ho HY,Lo SJ, Chiu DTY (2013.5) Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditiselegans. Cell Death & Disease. 4:e616.doi: 10.1038/cddis.2013.132  (SCI IF=5.177)

9. Ho HY, Cheng ML*, Shiao MS, Chiu DTY. (2013) Characterization of Global Metabolic Responses of G6PD-Deficient Hepatoma Cells to Diamide-Induced Oxidative Stress. Free Radical Biology & Medicine 54:71-84(SCI IF=5.710)(*Co-first author paper)

10. Chen YC, Chen CM, Liu JL, Chen ST, Cheng ML#, Chiu DTY. (2011) Oxidative markers in spontaneous intracerebral hemorrhage: leukocyte 8-hydroxy-2'-deoxyguanosine as an independent predictor of the 30-day outcome. Journal of Neurosurgery115:1184-1190 (SCI IF=3.227) ( #Co-corresponding)

11. Chen KH, Cheng ML, Jing YH, Chiu DTY, Shiao MS, Chen JK. (2011) Resveratrol ameliorates metabolic disorders and muscle wasting in streptozotocin-induced diabetic rats. American Journal of Physiology-Endocrinology and Metabolism 301:E853-E863 (SCI IF=4.088)

12. Cheng ML, Shiao MS, Chiu DTY, Weng SF, Tang HY, Ho HY (2011)Biochemicaldisordersassociated with antiproliferativeeffect of dehydroepiandrosterone in hepatoma cells as revealed by LC-based metabolomics. Biochemical Pharmacology 82:1549-1561(SCI IF=4.650)

13. Lin YS, Chen CM, Soong BW, Wu YR, Chen HM, Yeh WY, Wu DR, Lin YJ, Poon PW, Cheng ML, Wang CH, Chern Y(2011)Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease.Journal of Clinical Investigation 121:1519-1523(SCI IF=13.765)

14. Yang HC, Cheng ML*, Ho HY, Chiu DTY (2011)Themicrobicidal and cytoregulatory roles of NADPH oxidases.Microbes and Infection 13:109-120(SCI IF=2.731)(*Co-first author paper)

15. Lin CJ, Ho HY, Cheng ML, Cheng TH. Yu JS, Chiu DTY(2010) Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H2O2-induced apoptosis. Free Radical Biology & Medicine  49:361-373(SCI IF=5.710)