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  4. 楊雅晴(Ya-Chin Yang)

楊雅晴(Ya-Chin Yang)

Ya-Chin Yang

Position

Professor

Education

Ph. D., Department of Physiology, National Taiwan University College of Medicine, Taiwan

E-mail

ycyang@mail.cgu.edu.tw

Office Tel

+886-3-211-8800 ext.3394

Fax

+886-3-211-8700

Laboratory

神經訊號傳遞與迴路功能實驗室

Spciality

Neurobiology

Lab & Research Interest

 
Information processing by neural circuits in the mammalian brain

Publications

Publications:

  1. C.-H. Tai, M.-K. Pan, J. J. Lin, C.-S. Huang, Y.-C. Yang* and C.-C. Kuo* (2012) Subthalamic discharges as a causal determinant of parkinsonian motor deficits. Annals of Neurology (in press) (*Corresponding Author)
  2. C.-H. Tai#, Y.-C. Yang#(co-first author), M.-K. Pan, C.-S. Huang, and C.-C. Kuo (2011) Modulation of subthalamic T-type Ca2+ channels remedies locomotor deficits in a rat model of Parkinson disease. #equal contribution. Journal of Clinical Investigation 121(8):3289-3305.
  3. Y.-C. Yang, S. Lin, P.-C. Chang, H.-C. Lin, and C.-C. Kuo (2011) Functional extension of amino acid triads from the fourth transmembrane segment (S4) into its external linker in Shaker K+ Channels. Journal of Biological Chemistry 286: 37503-37514
  4. Y.-C. Yang, C.-S. Huang, and C.-C. Kuo (2010) Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal Na+ channels. Anesthesiology 113(1):160-174
  5. Y.-C. Yang#, C.-H. Lee#, and C.-C. Kuo (2010) Ionic flow enhances low-affinity binding: a revised mechanistic view into Mg2+ block of NMDA receptors. #equal contribution. Journal of Physiology (London) 588(4):633-650
  6. Y.-C. Yang, J.-Y. Hsieh, and C.-C. Kuo (2009) The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na+ channel. Journal of General Physiology 134: 95-113
  7. Y.-C. Yang, C.-J. Own, and C.-C. Kuo (2007) A hydrophobic element secures S4 voltage sensor in position in the resting Shaker K+ channel. Journal of Physiology (London) 582(3):1059-1072
  8. Y.-C. Yang and C.-C. Kuo (2005) An inactivation stabilizer of the Na+ channel acts as an opportunistic pore blocker modulated by external Na+. Journal of General Physiology 125:465-481.
  9. C.-C. Kuo, W.-Y. Chen, and Y.-C. Yang (2004) Block of tetrodotoxin-resistant Na+ channel pore by multivalent cations: gating modification and Na+ flow dependence. Journal of General Physiology 124:27-42.
  10. Y.-C. Yang and C.-C. Kuo (2003) The position of the fourth segment of domain 4 determines status of the inactivation gate in Na+ channels. Journal of Neuroscience 23:4922-4930.
  11. Y.-C. Yang and C.-C. Kuo (2002) Inhibition of Na+ current by imipramine and related compounds: different binding kinetics as an inactivation stabilizer and as an open channel blocker. Molecular Pharmacology 62:1228-1237.