Department of Biomedical Sciences (Master's Program in Clinical Trials Assessment)

Sze-Cheng John Lo

Position

Professor

Education

Ph.D. Department of Biological Sciences, Wayne State University, USA

E-mail

losj@mail.cgu.edu.tw

Office Tel

+886-3-211-8800 ext.3295

Lab Tel

+886-3-211-8800 ext.3405

Fax

+886-3-211-8700

Laboratory

Virology and Developmental Biology

Specialty

Cell, Molecular and Developmental Biology

Lab & Research Interest

1. Molecular biology of hepatitis B and D viruses
2. Role of Nucleolar antigens in the development of Caenorhabditis elegans.
3. Nucleolar size control in C. elegans.

Publications

Publications:

1. Chen WW, Yi YH, Chien CH, Hsiung KC, Ma TH, Lin YC, Lo SJ*, & Chang TC*. (2016). Specific polyunsaturated fatty acids modulate lipid delivery and oocyte development in C. elegans revealed by molecular-selective label-free imaging. Scientific Reports. 6: 32021-32033.doi: 10.1038/srep32021.
    
2. Ma TH, Lee LW, Lee CC, Yi YH, Chan SP, Tan BC, Lo SJ*. (2016). Genetic control of nucleolar size: An evolutionary perspective. Nucleus. 7(2): 112-20.
    
3. Yi YH, Ma TH, Lee LW, Chiou PT, Chen PH, Lee CM, Chu YD, Yu H, Hsiung KC, Tsai YT, Lee CC, Chang YS, Chan SP*, Tan BCM*,Lo SJ*. (2015) A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans. PLoS Genet. 11(10):e1005580; doi:10.1371/journal.pgen.1005580.
    
4. Yu H, Lai HJ, Lin TW, Chen CS* and Lo SJ*. (2015) Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans. Biochem. J. 470: 145-154.
    
5. Yu H, Lai HJ, Lin TW, Lo SJ*. (2015) Autonomous and non-autonomous roles of DNase II during cell death in C. elegans embryos. Bioscience Rep. doi:10.1042/BSR20150055
    
6. Huang C-R, Lo SJ*. (2014). Hepatitis D virus infection, replication and cross-talk with the hepatitis B virus. World Journal of Gastroenterology. 40(20): 14589-14597.
    
7. C-C Lee*, Y-T Tsai*, C-W Kao, L-W Lee, H-J Lai, T-H Ma, Y-S Chang, N-H Yeh, and SJ Lo^#. (2014). Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans. Cell Death and Disease. 5, e1158; doi:10.1038/cddis.2014.114.
    
8. Yi YH^*, Chien CH^*, Chen WW, Ma TH, Liu KY, Chang YS, Chang TC^§, Lo SJ^§. (2014). Lipid droplet pattern and non-droplet like structure in two fat mutants of Caenorhabditis elegans revealed by coherent anti-Stokes Raman scattering (CARS) microscopy. J. Biomed.Opt. 19(1): O11011-1~7. ( ^*equal contribution; ^§corresponding author).
    
9. H-C Yang, T-L Chen, Y-H Wu, K-P Cheng, Y-H Lin, M-L Cheng, H-Y Ho, SJ Lo* and DT-Y Chiu*. (2013). Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans. Cell Death and Disease. 4, e616; doi : 10.1038/cddis. 2013. 132.
    
10. Huang CR, Wang RY, Hsu SC, Lo SJ*. (2012). Lysine-71 in the large delta antigen of hepatitis delta virus clade 3 modulates its localization and secretion. Virus Research. 170: 75-84.
     
11. Yi YH, Chang YS, Lin CH, Lew TS, Tang CY, Tseng WL, Tseng CP and Lo SJ*. (2012). Integrin-mediated membrane blebbing is dependent on sodium-proton exchanger 1 and sodium-calcium exchanger 1 activity. J. Biol. Chem. 287(13): 10316-10324.
     
12. Li LW, Lee CC, Huang CR, Lo SJ*. (2012). The nucleolus of Caenorhabditis elegans (invited review). J. Biomed. Biotechnol. 2012: 1-11.
     
13. Kuo SC, Chen YJ, Wang YM, Tsui PY, Kuo MD, Wu TY*, Lo SJ*. (2012). Cell-based analysis of Chikungunya virus E1 protein in membrane fusion. J. Biomed. Sci. 19: 44-55.
     
14. Lee LW, Chang TY, Lo HW, Lo SJ*. (2011). Hepatitis D antigens cause growth retardation and brood-size reduction in C. elegans. Frontiers Biosci. 3:380-390.
     
15. Kuo SC, Chen YJ, Wang YM, Kuo MD, Jinn TR, Chen WS, Chang YC, Tung KL, Wu TY*, Lo SJ**. (2011). Cell based analysis of Chikungunya virus membrane fusion using baculovirus-expression vectors. J. Virol. Methods. 175: 206-215.