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  4. 鄭美玲(Mei-Ling Cheng)

鄭美玲(Mei-Ling Cheng)

鄭美玲 (Mei-Ling Cheng)

職稱

Professor

最高學歷

Department of Biochemistry, National Taiwan University, Taiwan

E-mail

chengm@mail.cgu.edu.tw

電話：

+886-3-211-8800
ext.3811(office),3650(Lab)

傳真

+886-3-211-8700

實驗室

代謝體學實驗室

專長

代謝體學、自由基生物醫學及轉譯醫學

研究方向及研究室特色
  1. Oxidative stress and cell metabolism
  2. Study the role of oxidative stress on degenerative diseases
  3. LC/MS-based Metabolomic approach for degenerative disease study

論文與著作

Publications:

  1. Chang KH, Cheng ML*, Tang HY, Huang CY, Wu HC, Chen CM. (2022.1) Alterations of Sphingolipid and Phospholipid Pathways and Ornithine Level in the Plasma as Biomarkers of Parkinson's Disease. Cells 11(3): 395. (SCI IF=6.6) (*Co-first author paper)
  2. Cheng ML, Tang HY, Wu PT, Yang CH, Lo CJ, Lin JF, Ho HY. (2021.12) 7-Ketocholesterol Induces Lipid Metabolic Reprogramming and Enhances Cholesterol Ester Accumulation in Cardiac Cells. Cells 10(12): 3597. (SCI IF=6.6)
  3. Chiu CY, Cheng ML, Chiang MH, Wang CJ, Tsai MH, Lin G. (2021.12) Integrated metabolic and microbial analysis reveals host-microbial interactions in IgE-mediated childhood asthma. Scientific Reports 11(1): 23407. (SCI IF=4.38)
  4. Lin HT, Cheng ML, Lo CJ, Hsu WC, Lin G, Liu FC. (2021.11) 1H NMR metabolomic profiling of human cerebrospinal fluid in aging process. American Journal of Translational Research 13(11): 12495-12508. (SCI IF=4.06)
  5. Lin CN, Shiao MS, Cheng ML, Chen CM, Kuo HC. (2021.9) Profiling of Serum Metabolites of Acute Intermittent Porphyria and Asymptomatic HMBS Mutation Carriers. Cells 10(10): 2579. (SCI IF=6.6)
  6. Yeh TH, Liu HF, Chiu CC, Cheng ML, Huang GJ, Huang YC, Liu YC, Huang YZ, Lu CS, Chen YC, Chen HY, Cheng YC. (2021.9) PLA2G6 mutations cause motor dysfunction phenotypes of young-onset dystonia-parkinsonism type 14 and can be relieved by DHA treatment in animal models. Experimental Neurology 346:113863. (SCI IF=5.33)
  7. Lai YC, Hsieh CY, Lu KY, Sung CH, Ho HY, Cheng ML, Chen AP, Ng SH, Chen FH, Lin G. (2021.8) Monitoring Early Glycolytic Flux Alterations Following Radiotherapy in Cancer and Immune Cells: Hyperpolarized Carbon-13 Magnetic Resonance Imaging Study. Metabolites 11(8): 518. (SCI IF=4.932)
  8. Kuo WL, Tseng LL, Chang CC, Chen CJ, Cheng ML, Cheng HH, Wu MJ, Chen YL, Chang RT, Tang HY, Hsu YC, Lin WJ, Kao CY, Hsieh WP, Kung HJ, Wang WC. (2021.8) Prognostic Significance of O-GlcNAc and PKM2 in Hormone Receptor-Positive and HER2-Nonenriched Breast Cancer. Diagnostics (Basel) 11(8): 1460. (SCI IF=3.706)
  9. Wu MJ, Chen CJ, Lin TY, Liu YY, Tseng LL, Cheng ML, Chuu CP, Tsai HK, Kuo WL, Kung HJ, Wang WC. (2021.6) Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer. Theranostics 11(16): 7779-7796. (SCI IF=11.556)
  10. Hsu SC, Chen CL, Cheng ML, Chu CY, Changou CA, Yu YL, Yeh SD, Kuo TC, Kuo CC, Chuu CP, Li CF, Wang LH, Chen HW, Yen Y, Ann DK, Wang HJ, Kung HJ. (2021.6) Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genes. Theranostics 11(15): 7527-7545. (SCI IF=11.556)
  11. Huang CF, Chen A, Lin SY, Cheng ML, Shiao MS, Mao TY. (2021.5) A metabolomics approach to investigate the proceedings of mitochondrial dysfunction in rats from prediabetes to diabetes. Saudi Journal of Biological Sciences 28(8): 4762-4769. (SCI IF=4.219)
  12. Ma H, Zhang F, Zhou L, Cao T, Sun D, Wen S, Zhu J, Xiong Z, Tsau MT, Cheng ML, Hung LM, Zhou Y, Li Q. (2021.3) c-Src facilitates tumorigenesis by phosphorylating and activating G6PD. Oncogene 40(14): 2567-2580. (SCI IF=9.867)
  13. Huang YC, Cheng ML, Tang HY, Huang CY, Chen KM, Wang JS. (2021.2) Eccentric Cycling Training Improves Erythrocyte Antioxidant and Oxygen Releasing Capacity Associated with Enhanced Anaerobic Glycolysis and Intracellular Acidosis. Antioxidants 10(2): 285. (SCI IF=6.313)
  14. Tsai HI, Lo CJ, Lee CW, Lin JR, Lee WC, Ho HY, Tsai CY, Cheng ML#, Yu HP. (2021.1) A panel of biomarkers in the prediction for early allograft dysfunction and mortality after living donor liver transplantation. American Journal of Translational Research 13(1): 372-382. (SCI IF=4.060) (#Co-corresponding)
  15. Cheng CW, Liu MH, Tang HY, Cheng ML, Wang CH. (2021.1) Factors associated with elevated plasma phenylalanine in patients with heart failure. Amino Acids 53(2): 149-157. (SCI IF= 3.520)
  16. Lo CJ, Ko YS, Chang SW, Tang HY, Huang CY, Huang YC, Ho HY, Lin CM, Cheng ML. (2020.12) Metabolic signatures of muscle mass loss in an elderly Taiwanese population. Aging 13(1):944-956. (SCI IF= 5.682)
  17. Tang HY, Wang CH, Ho HY, Lin JF, Lo CJ, Huang CY, Cheng ML. (2020.10) Characteristic of Metabolic Status in Heart Failure and Its Impact in Outcome Perspective. Metabolites 10(11): E437. (SCI IF=4.932)
  18. Chen WS, Liu MH, Cheng ML, Wang CH. (2020.9) Decreases in Circulating Concentrations of Short-Chain Acylcarnitines are Associated with Systolic Function Improvement After Decompensated Heart Failure. International Heart Journal 61(5):1014-1021. (SCI IF= 1.862)
  19. Huang JP, Cheng ML, Wang CH, Huang SS, Hsieh PS, Chang CC, Kuo CY, Chen KH, Hung LM. (2020.9) Therapeutic potential of cPLA2 inhibitor to counteract dilated-cardiomyopathy in cholesterol-treated H9C2 cardiomyocyte and MUNO rat. Pharmacological Research 160: 105201. (SCI IF= 7.658)
  20. Chang-Chien J, Huang HY, Tsai HJ, Lo CJ, Lin WC, Tseng YL, Wang SL, Ho HY, Cheng ML#, Yao TC. (2020.9) Metabolomic differences of exhaled breath condensate among children with and without asthma. Pediatric Allergy and Immunology 32(2): 264-272. (SCI IF= 6.377) (#Co-corresponding)
  21. Liang KH, Cheng ML*, Lo CJ, Lin YH, Lai MW, Lin WR, Yeh CT. (2020.7) Plasma phenylalanine and glutamine concentrations correlate with subsequent hepatocellular carcinoma occurrence in liver cirrhosis patients: an exploratory study. Scientific Reports 10(1):10926. (SCI IF=4.38) (*Co-first author paper)
  22. Chiu CY, Cheng ML, Chiang MH, Wang CJ, Tsai MH, Lin G. (2020.3) Metabolomic Analysis Reveals Distinct Profiles in the Plasma and Urine Associated with IgE Reactions in Childhood Asthma. Journal of Clinical Medicine 9(3): E887. (SCI IF=4.242)
  23. Ma H, Zhang J, Zhou L, Wen S, Tang HY, Jiang B, Zhang F, Suleman M, Sun D, Chen A, Zhao W, Lin F, Tsau MT, Shih LM, Xie C, Li X, Lin D, Hung LM, Cheng ML#, Li Q. (2020.3) c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3. Cell Reports 30(12): 4235-4249. (SCI IF=9.423) (#Co-corresponding)
  24. Cheng ML, Chien KY, Lai CH, Li GJ, Lin JF, Ho HY. (2020.2) Metabolic Reprogramming of Host Cells in Response to Enteroviral Infection. Cells 9(2): E473. (SCI IF=6.6)
  25. Weng WC, Huang WY, Tang HY, Cheng ML, Chen KH. (2019.11) The Differences of Serum Metabolites Between Patients With Early-Stage Alzheimer's Disease and Mild Cognitive Impairment. Frontiers in Neurology 10: 1223. (SCI IF=4.003)
  26. Cheng SC, Chen K, Chiu CY, Lu KY, Lu HY, Chiang MH, Tsai CK, Lo CJ, Cheng ML, Chang TC, Lin G. (2019.10) Metabolomic biomarkers in cervicovaginal fluid for detecting endometrial cancer through nuclear magnetic resonance spectroscopy. Metabolomics 15(11): 146. (SCI IF=4.290)
  27. Lin HT, Cheng ML*, Lo CJ, Lin G, Lin SF, Yeh JT, Ho HY, Lin JR, Liu FC. (2019.6) 1H Nuclear Magnetic Resonance (NMR)-Based Cerebrospinal Fluid and Plasma Metabolomic Analysis in Type 2 Diabetic Patients and Risk Prediction for Diabetic Microangiopathy. Journal of Clinical Medicine 8(6): E874. (SCI IF=4.242) (*Co-first author paper)
  28. Wang CH, Cheng ML, Liu MH, Fu TC. (2019.5) Amino Acid-Based Metabolic Profile Provides Functional Assessment and Prognostic Value for Heart Failure Outpatients. Disease Markers 2019: 8632726. (SCI IF=3.434)
  29. Lee TH, Cheng ML*, Shiao MS, Lin CN. (2019.6) Metabolomics study in severe extracranial carotid artery stenosis. BMC Neurology 19(1): 138. (SCI IF=2.474) (*Co-first author paper)
  30. Chiu CY, Cheng ML, Chiang MH, Kuo YL, Tsai MH, Chiu CC, Lin G. (2019.6) Gut microbial-derived butyrate is inversely associated with IgE responses to allergens in childhood asthma. Pediatric Allergy and Immunology 30(7): 689-697. (SCI IF=6.377)
  31. Huang SS, Lin JY, Chen WS, Liu MH, Cheng CW, Cheng ML, Wang CH. (2019.8) Phenylalanine and leucine-defined metabolic types identify high mortality risk in patients with severe infection. International Journal of Infectious Diseases 85: 143-149. (SCI IF=3.623)
  32. Hung CY, Yeh TS, Tsai CK, Wu RC, Lai YC, Chiang MH, Lu KY, Lin CN, Cheng ML, Lin G. (2019.3) Glycerophospholipids pathways and chromosomal instability in gastric cancer: Global lipidomics analysis. World Journal of Gastrointestinal Oncology 11(3):181-194. (SCI IF=3.393)
  33. Yang CH, Liang CT, Jiang ST, Chen KH, Yang CC, Cheng ML, Ho HY. (2019.5) A Novel Murine Model Expressing a Chimeric mSCARB2/hSCARB2 Receptor Is Highly Susceptible to Oral Infection with Clinical Isolates of Enterovirus 71. Journal of Virology 93(11):e00183-19.( SCI IF=5.103)
  34. Chiu CY, Cheng ML, Wong KS, Lai SH, Chiang MH, Tsai MH, Lin G. (2019.3) Metabolomics Reveals Anaerobic Bacterial Fermentation and Hypoxanthine Accumulation for Fibrinous Pleural Effusions in Children with Pneumonia. Journal of proteome research 18(3):1248-1254. (SCI IF=4.466)
  35. Cheng ML, Lin JF, Huang CY, Li GJ, Shih LM, Chiu DT, Ho HY. (2019.1) Sedoheptulose-1,7-bisphospate Accumulation and Metabolic Anomalies in Hepatoma Cells Exposed to Oxidative Stress. Oxidative Medicine and Cellular Longevity 2019:5913635. (SCI IF=6.543)
  36. Chen IC, Chang CN, Chen WL, Lin TH, Chao CY, Lin CH, Lin HY, Cheng ML, Chiang MC, Lin JY, Wu YR, Lee-Chen GJ, Chen CM. (2019.1) Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3. The American Journal of Chinese Medicine 47(1): 63-95. (SCI IF=4.667)
  37. Lynn KS, Cheng ML, Yang HC, Liang YJ, Kang MJ, Chen FL, Shiao MS, Pan WH. (2019.1) Vegetable signatures derived from human urinary metabolomic data in controlled feeding studies. Journal of proteome research 18(1): 159-168. (SCI IF=4.466)
  38. Tsai HI, Lo CJ, Zheng CW, Lee CW, Lee WC, Lin JR, Shiao MS, Cheng ML#, Yu HP. (2018.12) A Lipidomics Study Reveals Lipid Signatures Associated with Early Allograft Dysfunction in Living Donor Liver Transplantation. Journal of clinical medicine 8(1):E30. (SCI IF=4.242) (#Co-corresponding)
  39. Lo CJ, Tang HY, Huang CY, Lin CM, Ho HY, Shiao MS, Cheng ML. (2018.12) Metabolic Signature Differentiated Diabetes Mellitus from Lipid Disorder in Elderly Taiwanese. Journal of clinical medicine 8(1):E13. (SCI IF=4.242)
  40. Wang CH, Cheng ML, Liu MH. (2018.10) Amino Acid-Based Metabolic Panel Provides Robust Prognostic Value Additive to B-Natriuretic Peptide and Traditional Risk Factors in Heart Failure. Disease Markers 2018:3784589. (SCI IF=3.434)
  41. Shih LM, Tang HY, Lynn KS, Huang CY, Ho HY, Cheng ML. (2018.11) Stable Isotope-Labeled Lipidomics to Unravel the Heterogeneous Development Lipotoxicity. Molecules 23(11):E2862. (SCI IF= 4.412)
  42. Wang CH, Cheng ML, Liu MH. (2018.9) Simplified plasma essential amino acid-based profiling provides metabolic information and prognostic value additive to traditional risk factors in heart failure. Amino Acids 50(12):1739-1748. (SCI IF= 3.520)
  43. Tsai CK, Yeh TS, Wu RC, Lai YC, Chiang MH, Lu KY, Hung CY, Ho HY, Cheng ML, Lin G. (2018.9) Metabolomic alterations and chromosomal instability status in gastric cancer. World Journal of Gastroenterology 24(33):3760-3769. (SCI IF=5.742)
  44. Lin WC, Chakraborty A, Huang SC, Wang PY, Hsieh YJ, Chien KY, Lee YH, Chang CC, Tang HY, Lin YT, Tung CS, Luo JD, Chen TW, Lin TY, Cheng ML, Chen YT, Yeh CT, Liu JL, Sung LY, Shiao MS, Yu JS, Chang YS, Pai LM. (2018.9) Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase. Cell Reports 24(10):2733-2745. (SCI IF=9.423)
  45. Chung YH, Lu KY, Chiu SC, Lo CJ, Hung LM, Huang JP, Cheng ML, Wang CH, Tsai CK, Lin YC, Chang SH, Lin G. (2018.7) Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer. Contrast Media & Molecular Imaging 2018:8751267. (SCI IF=3.161)
  46. Chen KH, Chen YL, Tang HY, Hung CC, Yen TH, Cheng ML, Shiao MS, Chen JK. (2018.6) Dietary Leucine Supplement Ameliorates Hepatic Steatosis and Diabetic Nephropathy in db/db Mice. International Journal of Molecular Sciences 19(7):E1921. (SCI IF=5.924)
  47. Chang KH, Cheng ML, Chiang MC, Chen CM. (2018.6) Lipophilic antioxidants in neurodegenerative diseases. Clinica Chimica Acta 485:79-87. (SCI IF=3.786)
  48. Chiu CY, Lin G, Cheng ML, Chiang MH, Tsai MH, Su KW, Hua MC, Liao SL, Lai SH, Yao TC, Yeh KW, Huang JL. (2018.7) Longitudinal urinary metabolomic profiling reveals metabolites for asthma development in early childhood. Pediatric Allergy and Immunology 29(5): 496-503. (SCI IF= 6.377)
  49. Chang SW, Cheng ML, Shiao MS, Yeh CT, Wang CH, Fan CM, Chiu CT, Chang ML. (2018.2) Recovery of lipid metabolic alterations in hepatitis C patients after viral clearance: Incomplete restoration with accelerated ω-oxidation. Journal of Clinical Lipidology 12(3):756-766. (SCI IF=4.766)
  50. Chang KH, Cheng ML*, Tang HY, Huang CY, Wu YR, Chen CM. (2018.1) Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson’s Disease. Molecular Neurobiology 55(8):6319-6328. (SCI IF= 5.59) (*Co-first author paper)
  51. Tang HY, Wang CH, Ho HY, Wu PT, Hung CL, Huang CY, Wu PR, Yeh YH, Cheng ML. (2018.4) Lipidomics reveals accumulation of the oxidized cholesterol in erythrocytes of heart failure patients. Redox Biology 14:499-508. (SCI IF=11.799)
  52. Sun CY, Cheng ML, Pan HC, Lee JH, Lee CC. (2017.9) Protein-bound uremic toxins impaired mitochondrial dynamics and functions. Oncotarget 8(44):77722-77733. (SCI IF=5.168)
  53. Cheng WH, Huang KY, Huang PJ, Lee CC, Yeh YM, Ku FM, Lin R, Cheng ML, Chiu CH, Tang P. (2017.9) γ-Carboxymuconolactone decarboxylase: a novel cell cycle-related basal body protein in the early branching eukaryote Trichomonas vaginalis. Parasites & Vectors 10(1):443. (SCI IF=3.876)
  54. Chen SG, Leu YL, Cheng ML, Ting SC, Liu CC, Wang SD, Yang CH, Hung CY, Sakurai H, Chen KH, Ho HY. (2017.9) Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid. Scientific Reports 7(1):12264. (SCI IF=4.38)
  55. Tang HY, Chiu DT, Lin JF, Huang CY, Chang KH, Lyu RK, Ro LS, Kuo HC, Cheng ML#, Chen CM. (2017.8) Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome. Scientific Reports 7(1):8140. (SCI IF=4.38) (#Co-corresponding)
  56. Lin YH, Wu MH, Huang YH, Yeh CT, Cheng ML, Chi HC, Tsai CY, Chung IH, Chen CY, Lin KH. (2017.8) Taurine upregulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma. Hepatology 67(1): 188-203. (SCI IF=17.425)
  57. Wu HQ, Cheng ML*, Lai JM, Wu HH, Chen MC, Liu WH, Wu WH, Chang PM, Huang CF, Tsou AP, Shiao MS, Wang FS. (2017.7) Flux balance analysis predicts Warburg-like effects of mouse hepatocyte deficient in miR-122a. PLOS Computational Biology 13(7):e1005618. (SCI IF=4.475) (*Co-first author paper)
  58. Ho HY, Lin YT, Lin G, Wu PR, Cheng ML. (2017.4) Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation. Redox Biology 12:916-928. (SCI IF=11.799)
  59. Tang HY, Ho HY, Chiu DT, Huang CY, Cheng ML#, Chen CM. (2017.5) Alterations of plasma concentrations of lipophilic antioxidants are associated with Guillain-Barre syndrome. Clinica Chimica Acta 470:75-80. (SCI IF=3.786) (#Co-corresponding)
  60. Chen SG, Cheng ML, Chen KH, Horng JT, Liu CC, Wang SM, Sakurai H, Leu YL, Wang SD, Ho HY. (2017.4) Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo. Scientific Reports 7(1):935. (SCI IF=4.38)
  61. Wang CH, Cheng ML, Liu MH, Kuo LT, Shiao MS. (2017.5) Metabolic profile provides prognostic value better than galectin-3 in patients with heart failure. Journal of Cardiology 70(1):92-98. (SCI IF=3.159)
  62. Chen TL, Yang HC, Hung CY, Ou MH, Pan YY, Cheng ML, Stern A, Lo SJ, Chiu DT. (2017.1) Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism. Cell Death and Disease 8(1):e2545. (SCI IF=8.469)
  63. Huang JP, Cheng ML, Hung CY, Wang CH, Hsieh PS, Shiao MS, Chen JK, Li DE, Hung LM. (2017.10) Docosapentaenoic acid and docosahexaenoic acid are positively associated with insulin sensitivity in rats fed high-fat and high-fructose diets. Journal of Diabetes 9(10):936-946. (SCI IF=4.006)
  64. Chang ML, Cheng ML#, Chang SW, Tang HY, Chiu CT, Yeh CT, Shiao MS. (2016.11) Recovery of pan-genotypic and genotype-specific amino acid alterations in chronic hepatitis C after viral clearance: transition at the crossroad of metabolism and immunity. Amino Acids 49(2):291-302 (SCI IF=3.520) (#Co-corresponding)
  65. Cheng ML, Chi LM, Wu PR, Ho HY (2016.10) Dehydroepiandrosterone-induced changes in mitochondrial proteins contribute to phenotypic alterations in hepatoma cells. Biochemical Pharmacology 117:20-34 (SCI IF=5.858)
  66. Huang JP, Cheng ML*, Wang CH, Shiao MS, Chen JK, Hung LM. (2016.7) High-fructose and high-fat feeding correspondingly lead to the development of lysoPC-associated apoptotic cardiomyopathy and adrenergic signaling-related cardiac hypertrophy. International Journal of Cardiology 215:65-76 (SCI IF=4.164) (*Co-first author paper)
  67. Wang CH, Cheng ML#, Liu MH, Shiao MS, Hsu KH, Huang YY, Lin CC, Lin JF. (2016.7) Increased p-cresyl sulfate level is independently associated with poor outcomes in patients with heart failure. Heart and Vessels 7:1100-8 (SCI IF=2.037) (#Co-corresponding)
  68. Cheng ML, Chang KH, Wu YR, Chen CM. (2016.5) Metabolic disturbances in plasma as biomarkers for Huntington's disease. Journal of Nutritional Biochemistry 31:38-44 (SCI IF=6.048)
  69. Chiu CY, Lin G, Cheng ML, Chiang MH, Tsai MH, Lai SH, Wong KS, Hsieh SY. (2016.4) Metabolomic Profiling of Infectious Parapneumonic Effusions Reveals Biomarkers for Guiding Management of Children with Streptococcus pneumoniae Pneumonia. Scientific Reports 6:24930 (SCI IF=4.38)
  70. Martel J, Wu CY, Hung CY, Wong TY, Cheng AJ, Cheng ML, Shiao MS, Young JD. (2016.3) Fatty acids and small organic compounds bind to mineralo-organic nanoparticles derived from human body fluids as revealed by metabolomic analysis. Nanoscale 8(10):5537-45. (SCI IF=7.790)
  71. Chiu CY, Yeh KW, Lin G, Chiang MH, Yang SC, Chao WJ, Yao TC, Tsai MH, Hua MC, Liao SL, Lai SH, Cheng ML#, Huang JL. (2016.2) Metabolomics Reveals Dynamic Metabolic Changes Associated with Age in Early Childhood. PLoS ONE 11(2): e0149823 (SCI IF=3.240) (#Co-corresponding)
  72. Tsai WC, Yu TY, Lin LP, Cheng ML, Chen CL, Pang JS. (2016.2) Prevention of simvastatin-induced inhibition of tendon cell proliferation and cell cycle progression by geranylgeranyl pyrophosphate. Toxicological Sciences 149(2):326-34 (SCI IF=4.849)
  73. Wu YH, Chiu DT, Lin HR, Tang HY, Cheng ML, Ho HY. (2015.12) Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling. Viruses 7(12), 6689-6706 (SCI IF=5.048)
  74. Wang PY, Lin WC, Tsai YC, Cheng ML, Lin YH, Tseng SH, Chakraborty A, Pai LM. (2015.12) Regulation of CTP Synthase Filament Formation During DNA Endoreplication in Drosophila. Genetics 201(4):1511-23 (SCI IF=4.562)
  75. Yeh YH, Kuo CT, Chang GJ, Chen YH, Lai YJ, Cheng ML, Chen WJ. (2015.5) Rosuvastatin suppresses atrial tachycardia-induced cellular remodeling via Akt/Nrf2/heme oxygenase-1 pathway. Journal of Molecular and Cellular Cardiology 82:84-92 (SCI IF=5.000)
  76. Yang HC, Cheng ML*, Hua YS, Wu YH, Lin HR, Liu HY, Ho HY, Chiu DT. (2015.4) Glucose 6-phosphate dehydrogenase knockdown enhances IL-8 expression in HepG2 cells via oxidative stress and NF-κB signaling pathway. Journal of Inflammation-London 12:34 (SCI IF=4.981) (*Co-first author paper)
  77. Cheng ML, Wang CH, Shiao MS, Liu MH, Huang YY, Huang CY, Mao CT, Lin JF, Ho HY, Yang NI. (2015.4) Metabolic Disturbances Identified in Plasma Are Associated With Outcomes in Patients With Heart Failure: Diagnostic and Prognostic Value of Metabolomics. Journal of The American College of Cardiology 65(15):1509-20 (SCI IF=24.093) 
  78. Tang HY, Ho HY, Wu PR, Chen SH, Kuypers FA, Cheng ML*#, Chiu DT. (2015.3) Inability to Maintain GSH Pool in G6PD-Deficient Red Cells Causes Futile AMPK Activation and Irreversible Metabolic Disturbance. Antioxidants & Redox Signaling 22(9):744-59 (SCI IF=8.401) (*Co-first author paper) (#Co-corresponding)
  79. Lynn KS, Cheng ML, Chen YR, Hsu C, Chen A, Lih TM, Chang HY, Huang CJ, Shiao MS, Pan WH, Sung TY, Hsu WL. (2015.2) Metabolite identification for mass spectrometry-based metabolomics using multiple types of correlated ion information. Analytical Chemistry 87(4):2143-51 (SCI IF=6.986)