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蘇文慧(Wen-Hui Su)

蘇文慧 (Wen-Hui Su)

職稱

副教授

最高學歷

國防醫學院 博士

E-mail

whsu@mail.cgu.edu.tw

電話：

+886-3-211-8800
3564(office),3528(Lab)

傳真

+886-3-211-8700

實驗室

癌症系統生物學研究室

專長

生物資訊、癌症基因體學、分子流行病學

研究方向及研究室特色

   癌症做為一種遺傳的疾病，許多關於癌症的變化，常是先在染色體中發生，進而影響基因的表現，而導致癌症發生，或形成癌症特殊的標誌。我們在染色體上找到與癌症相關的變化，可以分為兩大類。一類為在生殖細胞(germline cells)就有的變異，例如單一核酸變異(SNP)或是複製數變異(copy number variation)，讓帶有這些變異或基因型的人較其他人更容易得病，我們可以利用全基因體關聯性分析(genome-wide association study) 的方法，來研究有哪些變異會造成對疾病的感受性的差異。進而去找到造成這種感受性差異的癌症基因。另一類，則是在體細胞(somatic cells)中成形的癌組織內，常會見到的是染色體畸變(chromosome aberration)和基因表現改變的現象，我們也可以利用生物資訊和比較基因體學的方法，將目前已有的這些資訊整合起來，試著找出與癌症的標誌基因。在我們實驗室裏，就是試著以系統生物學和遺傳統計的方法，將這些訊息進行整合，試著找出與鼻咽癌(nasopharyngeal carcinoma)和肝癌(hepatocellular carcinoma)相關的感受性標誌及標誌基因。

論文與著作

Publications:

  1. Wang Jin, Zhao Lei, Sun Xu, Zhou Fachen, Zhang Yixiang, Zhao Shilei, Guo Tao, Sun Zhe, Li Fengzhou, Wen-Hui Su, and Gu Chundong (2021) Genetic Mutation Analysis in Small Cell Lung Cancer by a Novel NGS-Based Targeted Resequencing Gene Panel and Relation with Clinical Features. BioMed Research International 2021 Article ID 3609028.
  2. Muyun Peng, Qi Huang, Wei Yin, Sichuang Tan, Chen Chen, Wenliang Liu, Jingqun Tang, Xiang Wang, Bingyu Zhang, Min Zou, Jina Li, Wenhui Su, Lientu Wang, Lihan Chin and Fenglei Yu (2020) Circulating Tumor DNA as a Prognostic Biomarker in Localized Non-small Cell Lung Cancer. Frontiers in Oncology 10: 1875
  3. Xiao-Yu Zuo, Qi-Sheng Feng, Jian Sun, Pan-Pan Wei, Yoon-Ming Chin, Yun-Miao Guo, Yun-Fei Xia, Bo Li, Xiao-Jun Xia, Wei-Hua Jia, Jian-Jun Liu, Alan Soo-Beng Khoo, Taisei Mushiroda, Ching-Ching Ng*†, Wen-Hui Su†, Yi-Xin Zeng†, and Jin-Xin Bei† (2019) X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma. Biology of Sex Differences 10:13 (†equal contributed corresponding author)
  4. Wen-Hui Su*, Yuh-Shan Jou, Jia-Hao Zhang, Chun-Ming Ho, Dar-In Tai (2018) Mutations in NOTCH1 and nucleotide excision repair genes are correlated with prognosis of hepatitis B virus-associated hepatocellular carcinoma. Journal of Cancer 9(15): 2678-2686 (*Corresponding author)
  5. The Telomeres Mendelian Randomization Collaboration (2017) Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study. JAMA Oncology 3(5):636-651
  6. Jin-Xin Bei†, Wen-Hui Su†, Ching-Ching Ng†, Kai Yu, Yoon-Ming Chin, Pei-Jen Lou, Wan-Lun Hsu, James D. McKay, Chien-Jen Chen, Yu-Sun Chang, Jian-Jun Liu, Yi-Xin Zeng, and Allan Hildesheim for the International Nasopharyngeal Carcinoma Genetics Working Group (2016) A GWAS meta-analysis and replication study identifies a novel locus within CLPTM1L/TERT associated with nasopharyngeal carcinoma in individuals of Chinese ancestry. Cancer Epidemiology Biomarkers & Prevention 25(1):188-92 (†equal contributed first author)
  7. Wen-Hui Su*, Chi-Cking Chiu, Yin Yao Shugart (2015) Heterogeneity revealed through meta-analysis might link geographical differences with nasopharyngeal carcinoma incidence in Han Chinese population. BMC Cancer 15:598. (*Corresponding author)
  8. Su-Wei Chang, Cathy Shen-Jang Fann, Wen-Hui Su, Yu Chen Wang, Chia Chan Weng, Chia-Jung Yu, Chia-Lin Hsu, Ai-Ru Hsieh, Rong-Nan Chien, Chia-Ming Chu, Dar-In Tai (2014) A Genome-Wide Association Study on Chronic HBV Infection and Its Clinical Progression in Male Han-Taiwanese. PLoS One 9(6):e99724.
  9. Wen-Hui Su*, Yin Yao Shugart, Kai-Ping Chang, Ngan-Ming Tsang, Ka-Po Tse, and Yu-Sun Chang (2013) How Genome-Wide SNP-SNP Interactions Relate to Nasopharyngeal Carcinoma Susceptibility. PLoS One 8(12):e83034. (*Corresponding author)
  10. Wen-Hui Su*, Allan Hildesheim, and Yu-Sun Chang (2013) Human Leukocyte Antigens and Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma: Old Associations Offer New Clues into the Role of Immunity in Infection-Associated Cancers. Frontiers in Oncology 3(299):1-9. (Invited Review) (*Corresponding author)
  11. Wan-Lun Hsu, Ka-Po Tse, Sharon Liang, Yin-Chu Chien, Wen-Hui Su, Kelly Yu, Yu-Juen Cheng, Ngan-Ming Tsang, Mow-Ming Hsu, Kai-Ping Chang, I-How Chen, Tzu-I Chen, Czau-Siung Yang, Alisa Goldstein, Chien-Jen Chen, Allan Hildesheim, and Yu-Sun Chang (2012) Evaluation of Human Leukocyte Antigen-A (HLA-A), Other non-HLA Markers on Chromosome 6p21 and Risk of Nasopharyngeal Carcinoma. PLoS One 7(8): e42767.
  12. Lin KT, Wang YW, Chen CT, Ho CM, Su WH, and Jou YS. (2012) HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. Clinical Cancer Research 18(17): 4691-4701.
  13. C-Y Chang, S-C Lin, W-H Su, C-M Ho, and Y-S Jou. (2012) Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma. Oncogene 31(21):2640-52.
  14. Sen Kao, Cheng-Kai Shiau, De-Leung Gu, Chun-Ming Ho, Wen-Hui Su, Chian-Feng Chen, Chi-Hung Lin, Yuh-Shan Jou. (2012) IGDB.NSCLC: Integrated Genomic Database of Non-Small Cell Lung Cancer. Nucleic Acids Research 40(Database issue): D972-7.
  15. Ka-Po Tse†, Wen-Hui Su†, Min-lee Yang, Hsiao-Yun Cheng, Ngan-Ming Tsang, Kai-Ping Chang, Sheng-Po Hao, Yin Yao Shugart, and Yu-Sun Chang. (2011) A gender-specific association of CNV at 6p21.3 with NPC susceptibility. Human Molecular Genetics 20(14):2889-2896. (SCI: Impact factor: 5.340, 23/166 GENETICS & HEREDITY) (†equal contributed first author)
  16. Chih-Ching Wu, Chia-Wei Hsu, Chi-De Chen, Chia-Jung Yu, Kai-Ping Chang, Dar-In Tai, Hao-Ping Liu, Wen-Hui Su, Yu-Sun Chang, and Jau-Song Yu (2010) Candidate Serological Biomarkers for Cancer Identified from the Secretomes of 23 Cancer Cell Lines and the Human Protein Atlas. Molecular and Cellular Proteomics 9(6):1100-17.
  17. Ka-Po Tse†, Wen-Hui Su†, Kai-Ping Chang, Ngan-Ming Tsang, Chia-Jung Yu, Petrus Tang, Lee-Chu See, Chuen Hsueh, Min-Lee Yang , Sheng-Po Hao, Hong-Yi Li, Ming-Hsi Wang, Li-Ping Liao, Lih-Chyang Chen, Sheue-Rong Lin, Yu-Sun Chang, and Yin Yao Shugart. (2009) Genome-wide association study reveals multiple nasopharyngeal Carcinoma-associated loci within the HLA region at chromosome 6p21.3. American Journal of Human Genetics 85(2):194-203  (†equal contributed first author) (NSC 99-3112-B-182-006)
  18. Wen-Hui Su, Chuan-Chuan Chao, Shiou-Hwei Yeh, Ding-Shinn Chen, Pei-Jer Chen, and Yuh-Shan Jou. (2007) OncoDB.HCC: An integrated genomic database of hepatocellular carcinoma revealed aberrant cancer target genes and loci. Nucleic Acids Research, 35:D727-D731.
  19. Ya-Hui Chang†, Wen-Hui Su†, Tso-Ching Lee, Hsiao-Fang Sunny Sun, Chia-Hsaing Chen, Wen-Harn Pan, Shih-Feng Tsai and Yuh-Shan Jou（2005）TPMD: A Database and Resources of Microsatellite Marker Genotyped in Taiwanese Populations. Nucleic Acids Research 33:D174-D177. (SCI: Impact factor: 10.162, 14/286 BIOCHEMISTRY & MOLECULAR BIOLOGY) (†equal contributed first author).