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  4. 羅時成(Sze-cheng John Lo)

羅時成(Sze-cheng John Lo)

羅時成 (Sze-Cheng John Lo)

職稱

教授

羅時成老師

最高學歷

美國偉恩州立大學生物科學系

E-mail

losj@mail.cgu.edu.tw

電話：

+886-3-211-8800 ext.3295

傳真

+886-3-211-8700

實驗室

病毒與發育生物學

專長

細胞、分子生物學、發育生物學

研究方向及研究室特色
  1. Liver organoid for HBV and HDV infection
  2. C. elegans as a model for nucleolus size control, human diseases and aging
  3. Aptamer applications for biological sciences and medicine

 

論文與著作

Publications (selected from 2010-present):

  1. Huang CR, Lo SJ* (2010). Evolution and diversity of the human hepatitis D virus genome. Adv Bioinformatics 2010:ID 323654. dot:10.1155/2010/323654.

  2. Lee LW, Lo HW, Lo SJ* (2010). Vectors for co-expression of two genes in Caenorhabditis elegans. Gene 455: 16-21.

  3. Lee LW, Chang TY, Lo HW,;Lo SJ*(2011) Hepatitis D antigens cause growth retardation and brood-size reduction in C. elegans. Frontiers in Biosciences E3: 380-390.

  4. Kuo, Chen YJ, Wang YM, Kuo MD, Jinn TR, Chen WS, Chang YC, Tung KL, Wu TY*, Lo SJ*. (2011) Cell-based analysis of Chikungunya virus membrane fusion using baculovirus-expression vectors. J. Virol. Meth. 175:206-215

  5. Yi YH, Chang YS, Lin CH, Lew TS, Tang CY, Tseng WL, Tseng CP and Lo SJ*. (2012) Integrin-mediated membrane blebbing is dependent on sodium-proton exchanger 1 and sodium-calcium exchanger 1 activity. J. Biol. Chem. 287:10316-24

  6. Li LW, Lee CC, Huang CR, Lo SJ*. (2012) The nucleolus of Caenorhabditis elegans (invited review). J. Biomed. Biotech. 601274. Epub 2012 Ap doi:10.1155/2012/601274

  7. Kuo SC, Chen YJ, Wang YM, Tsui PY, Kuo MD, Wu TY*, Lo SJ*. (2012) Cell-based analysis of Chikungunya virus E1 protein in membrane. J. Biomed. Sci. Apr 21;19(1):44. [Epub ahead of print]

  8. Huang CR, Wang RYL, Hsu SC, Lo SJ*. (2012) Lysine-71 in the large delta antigen of hepatitis delta virus clade 3 modulates its localization and secretion. Virus Res. 170:75-84.

  9. Yang HC, Chen TL, Wu YH, Cheng KP, Lin YH, Cheng ML, Ho HY, Lo SJ*, Chiu DT*. (2013) Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans. Cell Death Dis. 2013 May 2;4:e616. doi: 10.1038/cddis.2013.132.

  10. Yi YH, Chien CH, Chen WW, Ma TH, Liu KY, Chang YS, Chang TC*, Lo SJ*. (2014) Lipid droplet pattern and nondroplet-like structure in two fat mutants of Caenorhabditis elegans revealed by coherent anti-Stokes Raman scattering microscopy. J Biomed Opt. 2014 Jan 1;19(1):11011. doi: 10.1117/1.JBO.19.1.011011.

  11.  Lee CC, Tsai YT, Kao CW, Lee LW, Lai HJ, Ma TH, Chang YS, Yeh NH, Lo SJ*. (2014) Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans Cell Death Dis. 5, e1158; doi:10.1038/cddis.2014.114

  12. Huang CR, Lo SJ*. (2014) Hepatitis D infection, replication and cross-talk with the hepatitis B virus. World J. Gastroenterol 28; 20(40): 14589-14597.

  13. Yu H, Lai HJ, Lin TW, Lo SJ*. (2015) Autonomous and non-autonomous roles of DNase II during cell death in C. elegans embryos. Bioscience Rep doi:10.1042/BSR20150055

  14. Yu H, Lai HJ, Lin TW, Chen CS*, Lo SJ*. (2015) Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in C. elegans. Biochem J. doi:10.1042/BJ20150563

  15. Yi YH, Ma TH, Lee LW, Chiou PT, Lee CM, Chen PH, Chu YD, Yu H, Tsai YZ, Lee CC, Chang YS, Chan SP*, Tan BCM*, Lo SJ*. (2015) A genetic cascade of let-7-ncl-1-fib-1 modulates nucleolar size and rRNA biosynthesis in Caenorhabditis elegans PLoS Genetics doi:10.1371/journal.pgen.1065580

  16. Ma TH, Lee LW Lee CC, Yi YH, Chan SP*, Tan BCM*, Lo SJ*. (2016) Genetic control of nucleolar size: an evolutionary prospective. Nucleus DOI: 10.1080/19491034.2016.1166322

  17. Chen WW, Yi YH, Chien CH, Hsiung KC, Ma TH, Lin YC, Lo SJ*, Chang TC* (2016) Specific polyunsaturated fatty acids modulate lipid delivery and oocyte development in C. elegans revealed by molecular-selective label-free imaging. Scientific Rep 6:32021 | DOI: 10.1038 (Aug. 18, 2016)

  18. Chen TL, Yang HC, CY, Ou MH, YY, Cheng ML, Stern A, Lo SJ*, Chiu DTY* (2017) Impaired embryonic development in glucose 6-phosphate dehydrogenase deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism. Cell Death Dis. 8, e2545; doi:10.1038/cddis.2016.463 (Jan. 12, 2017)

  19. Chen YY, Lee LW, Hong WH, Lo SJ*. (2017) Expression of hepatitis B virus surface antigens induces defective gonad phenotypes in Caenorhabditis elegans. World J Virol (February) 12;(6):17-25.

  20. Yang HC, Hung CY, Pan YY, Lo SJ, Chiu D T-Y. (2017) Lipidomic analysis in Caenorhabditits elegans embryos. Bio-Protocol (Vol7, Iss18, Sep 205) DOI:10.21769/BioProtoc.2554

  21. Ma TH, Chen PH, Tan BCM, Lo SJ. (2018) Size scaling of nucleolus in Caenorhabditis elegans embryos. Biomedical Journal https://doi.org/10.1016/j.bj.2018.07.003.

  22. Yang HC, Yu H, Liu YC, Chen TL, Stern A, Lo SJ, Chiu DT (2019) IDH-1 deficiency induces growth defects and metabolic alterations in GSPD-1-deficient Caenorhabditis elegans. Mol Med (Berl). 2019 Jan 19. 97:385-396. doi: 10.1007/s00109-018-01740-2. [Epub ahead of print]

  23. Yang WH, Chen CY, Wang KL, Kwok HL, Stern A, Lo SJ, Yang HC. (2019) Reflex and habituation behavior of Caenorhabditis elegans assessed by a mechanical vibration and image analysis. J Neurosci Methods 2019 Aug 27:108415. doi: 10.1016/j.jneumeth.2019.108415. [Epub ahead of print]

  24. Chen PH, Chen YT, Chu TY, Ma TH, Wu MH, Lin HH, Chang YS, Tan BMC, Lo SJ. (2020). Nucleolar control by a non-apoptotic p53-caspases-deubiquitinylase axis promotes resistance to bacterial infection. FASEB Journal 34(1):1107-1121. doi: 10.1096/fj.201901959R. Epub 2019 Nov 29.

  25. Hsiung KC, Liu KY, Tsai TF, Yoshina S, Mitani S, Tan BCM, Lo SJ. (2020) Defects in CISD-1, a mitochondrial iron-sulfur protein, lower glucose level and ATP production in C. elegans. Biomedical J. 43(1):32-43