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羅時成(Sze-cheng John Lo)

Sze-Cheng John Lo




Ph.D. Department of Biological Sciences, Wayne State University, USA



Office Tel

+886-3-211-8800 ext.3295

Lab Tel

+886-3-211-8800 ext.3405




Virology and Developmental Biology


Cell, Molecular and Developmental Biology

Lab & Research Interest

  1. Molecular biology of hepatitis B and D viruses
  2. Role of Nucleolar antigens in the development of Caenorhabditis elegans.
  3. Nucleolar size control in C. elegans.



  1. Chen WW, Yi YH, Chien CH, Hsiung KC, Ma TH, Lin YC, Lo SJ*, & Chang TC*. (2016). Specific polyunsaturated fatty acids modulate lipid delivery and oocyte development in C. elegans revealed by molecular-selective label-free imaging. Scientific Reports. 6: 32021-32033.doi: 10.1038/srep32021.
  2. Ma TH, Lee LW, Lee CC, Yi YH, Chan SP, Tan BC, Lo SJ*. (2016). Genetic control of nucleolar size: An evolutionary perspective. Nucleus. 7(2): 112-20.
  3. Yi YH, Ma TH, Lee LW, Chiou PT, Chen PH, Lee CM, Chu YD, Yu H, Hsiung KC, Tsai YT, Lee CC, Chang YS, Chan SP*, Tan BCM*,Lo SJ*. (2015) A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans. PLoS Genet. 11(10):e1005580; doi:10.1371/journal.pgen.1005580.
  4. Yu H, Lai HJ, Lin TW, Chen CS* and Lo SJ*. (2015) Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans. Biochem. J. 470: 145-154.
  5. Yu H, Lai HJ, Lin TW, Lo SJ*. (2015) Autonomous and non-autonomous roles of DNase II during cell death in C. elegans embryos. Bioscience Rep. doi:10.1042/BSR20150055
  6. Huang C-R, Lo SJ*. (2014). Hepatitis D virus infection, replication and cross-talk with the hepatitis B virus. World Journal of Gastroenterology. 40(20): 14589-14597.
  7. C-C Lee*, Y-T Tsai*, C-W Kao, L-W Lee, H-J Lai, T-H Ma, Y-S Chang, N-H Yeh, and SJ Lo#. (2014). Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans. Cell Death and Disease. 5, e1158; doi:10.1038/cddis.2014.114.
  8. Yi YH*, Chien CH*, Chen WW, Ma TH, Liu KY, Chang YS, Chang TC§, Lo SJ§. (2014). Lipid droplet pattern and non-droplet like structure in two fat mutants of Caenorhabditis elegans revealed by coherent anti-Stokes Raman scattering (CARS) microscopy. J. Biomed.Opt. 19(1): O11011-1~7. ( *equal contribution; §corresponding author).
  9. H-C Yang, T-L Chen, Y-H Wu, K-P Cheng, Y-H Lin, M-L Cheng, H-Y Ho, SJ Lo* and DT-Y Chiu*. (2013). Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans. Cell Death and Disease. 4, e616; doi : 10.1038/cddis. 2013. 132.
  10. Huang CR, Wang RY, Hsu SC, Lo SJ*. (2012). Lysine-71 in the large delta antigen of hepatitis delta virus clade 3 modulates its localization and secretion. Virus Research. 170: 75-84.
  11. Yi YH, Chang YS, Lin CH, Lew TS, Tang CY, Tseng WL, Tseng CP and Lo SJ*. (2012). Integrin-mediated membrane blebbing is dependent on sodium-proton exchanger 1 and sodium-calcium exchanger 1 activity. J. Biol. Chem. 287(13): 10316-10324.
  12. Li LW, Lee CC, Huang CR, Lo SJ*. (2012). The nucleolus of Caenorhabditis elegans (invited review). J. Biomed. Biotechnol. 2012: 1-11.
  13. Kuo SC, Chen YJ, Wang YM, Tsui PY, Kuo MD, Wu TY*, Lo SJ*. (2012). Cell-based analysis of Chikungunya virus E1 protein in membrane fusion. J. Biomed. Sci. 19: 44-55.
  14. Lee LW, Chang TY, Lo HW, Lo SJ*. (2011). Hepatitis D antigens cause growth retardation and brood-size reduction in C. elegans. Frontiers Biosci. 3:380-390.
  15. Kuo SC, Chen YJ, Wang YM, Kuo MD, Jinn TR, Chen WS, Chang YC, Tung KL, Wu TY*, Lo SJ**. (2011). Cell based analysis of Chikungunya virus membrane fusion using baculovirus-expression vectors. J. Virol. Methods. 175: 206-215.