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蕭慧怡(Hui-Yi Hsiao)

蕭慧怡 (Hui-Yi Hsiao)

職稱

助理教授

xhy

最高學歷

美國紐約大學(PhD., Department of Biology, New York University, USA)

E-mail

ivyhsiao@mail.cgu.edu.tw

電話：

+886-3-211-8800 ext.3717

傳真

+886-3-211-8700

實驗室

組織工程與再生醫學實驗室

專長

組織工程、再生醫學、幹細胞生物學、淋巴水腫研究

研究方向及研究室特色

實驗室的研究有以下兩大方向：

  1.  組織工程應用於硬組織與軟組織的再生

組織工程的技術常被應用於再生醫學。組織工程的方式大多將細胞、生物材料和生長因子結合起來，促進組織再生來修復或替換受損組織。組織工程的研究主要致力於設促進血管生成和細胞分化以用來進行新組織的再生。我們的實驗室主要是結合成人幹細胞和生物材料來設計客製化的3D 組織結構，其後續可應用於不同組織的再生 (Fig. 1). 實驗室研究對於再生的組織的目標涵蓋了硬組織 （硬骨、軟骨）與軟組織 （脂肪、淋巴組織、毛髮）。

fig1

  1. 探討淋巴水腫的機制與治療的方針

淋巴水腫起因於淋巴回流受阻導致的组織間隙中多餘淋巴液体異常的堆積。淋巴水腫可分为原發性和繼發性淋巴水腫。原發性淋巴水腫主要是先天性的淋巴系统異常發育。繼發性淋巴水腫則是由感染、癌症或輻射導致淋巴系统受损引起的。在乳腺癌或婦科癌症患者进行腫瘤與淋巴结切除和放療後，大约有40％的乳腺癌患者和20-49％的婦科癌症患者出現淋巴回流功能異常的併發症，導致淋巴液堆積在組織當中造成淋巴水腫的現象。目前對於淋巴水腫的發展過程以及引起淋巴水腫症状的具体機制了解甚少。此外，如何治療或預防淋巴水腫的研究對於未来的臨床應用也非常重要。在我們的實驗室中，我們致力於研究淋巴水腫的機制，並尋找可行的淋巴水腫治療與預防的方法（Fig.2）。

fig2

論文與著作

Publications:

(Selected Publications)

  1. Hsiao HY, J.W. Liu, M. Pappalardo, M.H. Cheng, The Impacts of Lymph on the Adipogenesis of Adipose-Derived Stem Cells, Plast Reconstr Surg  (2023).

  1. Hsiao HY, W.C. Hsieh, F.C. Chang, J.W. Liu, W.L. Kuo, D.C. Cheong, J.J. Huang, The Effect of Negative Pressure on Wound Healing and Regeneration in Closed Incisions under High Tension: Evidence from Animal Studies and Clinical Experience, 2022 J Clin Med 12(1)

  1. Sakarya AH, Huang CW, Yang CY, Hsiao HY, Chang FC, Huang JJ. Vascularized lymph node transplantation successfully reverses lymphedema and maintains immunity in a rat lymphedema model. Bioeng Transl Med. 2022 Feb;7:e10301

  1. Hsiao HY, Nien CY, Hong HH, Cheng MH, Yen TH. Application of dental stem cells in three-dimensional tissue regeneration. World J Stem Cells 2021Nov;13:1610-24

5.     Huang CW, Chang YC, Hsiao HY, Liu JW, Chang FC, Huang JJ. Creation of a rat lymphedema model using extensive lymph node dissection and circumferential soft tissue resection: Is this a reliable model? Microsurgery 2021Nov;41:762-71.

6.     Hsiao HY, Lai CY, Liu JW, Yu YY, Chang FC, Huang JJ. Fate of Fat Grafting In Vivo and In Vitro: Does the Suction-Assisted Lipectomy Device Matter? Aesthet Surg J 2021 Sep ;41:NP1323-NP36.

7.     Hsiao HY, Cheng CM, Kao SW, et al. The effect of bone inhibitors on periosteum-guided cartilage regeneration. Sci Rep 2020 May;10:8372.

8.     Hsiao HY, Chung CW, Santos JH, Villaflores OB, Lu TT. Fe in biosynthesis, translocation, and signal transduction of NO: toward bioinorganic engineering of dinitrosyl iron complexes into NO-delivery scaffolds for tissue engineering. Dalton Trans 2019 Apr;48:9431-53.

9.     Hsiao HY, Yang CY, Liu JW, Brey EM, Cheng MH. Periosteal Osteogenic Capacity Depends on Tissue Source. Tissue Eng Part A 2018 Dec;24:1733-41.

10.  Yang CY, Ho OA, Cheng MH, Hsiao HY*. Critical Ischemia Time, Perfusion, and Drainage Function of Vascularized Lymph Nodes. Plast Reconstr Surg 2018 Sep;142:688-97.

11.   Ng CY, Yen H, Hsiao HY*, Su SC. Phytochemicals in Skin Cancer Prevention and Treatment: An Updated Review. Int J Mol Sci 2018 March;19(4):941

12. Hsiao HY, Yang SR, Brey EM, Chu IM, Cheng MH. Hydrogel Delivery of Mesenchymal Stem Cell-Expressing Bone Morphogenetic Protein-2 Enhances Bone Defect Repair. Plast Reconstr Surg Glob Open 2016 Aug;4:e838.

13.   Hsiao HY, Liu JW, Brey EM, Cheng MH. The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model. PLoS One 2016 Apr;11:e0154328.

14.   Hsiao HY, Jukam D, Johnston R, Desplan C. The neuronal transcription factor erect wing regulates specification and maintenance of Drosophila R8 photoreceptor subtypes. Dev Biol 2013 Sep;381:482-90.

15.   Hsiao HY, Johnston RJ, Jr., Jukam D, Vasiliauskas D, Desplan C, Rister J. Dissection and immunohistochemistry of larval, pupal and adult Drosophila retinas. J Vis Exp 2012 Nov:4347.

16.   Hsiao HY, He Q, Van Waasbergen LG, Grossman AR. Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways. J Bacteriol 2004 Jun;186:3882-8.