Jump to the main content block

黃國正 (Guo-Jen Huang)

Guo-Jen Huang


Assistant Professor


Ph.D., Department of Physiology, Development and Neuroscience,  University of Cambridge, UK



Office Tel

+886-3-211-8800 ext. 3802




Functional Neuroscience Lab


Genes and Neuroscience

Lab & Research Interest

  Understanding how the brain works is among the most important challenges to 21st century science. One structure in the brain that has received considerable attention is the hippocampus, which is considered to play a part in learning and emotional regulation. Intriguingly, even in adults, new neurons continue to be born within the hippocampus. Scientists have assumed that the function of these newly born neurons in the adult hippocampus are linked to learning and emotion.  Unfortunately, there is still no consensus on what functions these new neurons perform.  It is important to unveil factors controlling the activity of the progenitors of these new neurons, the neuronal stem cells, and to investigate the functions of newly-formed neurons.  Our current work is focus on three projects:

1)  What are the functions of adult born hippocampal neurons?
2)  How does exercise benefit our brain, and by what molecular mechanism?
3)  How to make the aging brain younger?  What are the candidate factors?

Selected Publications

 Publications:  (*corresponding author)       

  1. Chang S, Bok P, Tsai, CY, Sun CP, Liu H, Deussing  JM, Huang GJ*. NPTX2 is a key component in the regulation of anxiety. Neuropsychopharmacology  2018 Aug;43(9):1943-1953
  2. Chang S, Bok P, Sun CP, Edwards A, Huang GJ*. Neuropsin inactivation has protective effects against depressive-like behaviours and memory impairment induced by chronic stress. PLoS Genetics 2016 Oct 4; 12(10): e1006356
  3. Tsai CY, Tsai CY, Arnold S, Huang GJ*. Ablation of hippocampal neurogenesis in mice impairs the response to stress during the dark cycle. Nature Communications 2015 Sep 29;6:8373. doi: 10.1038/ncomms9373.
  4. Cai N, Chang S, Li Y, Li Q, Hu J, Liang J, Song L, Kretzschmar W, Gan X, Nicod J, Rivera M, Deng H, Du B, Li K, Sang W, Gao J, Gao S, Ha B, Ho HY, Hu C, Hu J, Hu Z, Huang G,  Jiang G, Jiang T,Jin W, Li G, Li K, Li Y, Li Y, Li Y, Lin YT, Liu L, Liu T, Liu Y, Liu Y, Lu Y, Lv L, Meng H, Qian P, Sang H, Shen J, Shi J, Sun J, Tao M, Wang G, Wang G, Wang J, Wang L, Wang X, Wang X, Yang H,Yang L, Yin Y, Zhang J, Zhang K, Sun N, Zhang W, Zhang X, Zhang Z, Zhong H, Breen G, Wang J,Marchini J, Chen Y, Xu Q, Xu X, Mott R*, Huang GJ*, Kendler K*, Flint J. Molecular signatures of major depression.Current Biology 2015 May 4;25(9):1146-56. (*co-senior author)
  5. Groves JO, Leslie IHuang GJ, McHugh SB, Taylor A, Mott R, Munafò M, Bannerman DM, Flint J. Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model. PLoS Genetics 2013;9(9):e1003718
  6. Huang GJ, Smith AL, Gray DH, Cosgrove C, Singer BH, Edwards A, Sims S, Parent JM, Johnsen A,Mott R, Mathis D, Klenerman P, Benoist C, Flint J. A genetic and functional relationship between T-cells and cellular proliferation in the adult hippocampus. PLoS Biology 2010 Dec 14; 8(12):e1000561
  7. Huang GJ, Shifman S, Johannesson M, Yalcin B, Valdar W, Taylor J, Mott R, Flint J. High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Research 2009 Jun; 19(6):1133-40
  8. Arnold S*, Huang GJ*( *equal contribution), Cheung A, Era T, Nishikawa SI, Bikoff E, Molnar E, Robertson E, Groszer M. The T-box transcription factor Tbr2/Eomes regulates neurogenesis in the cortical subventricular zone. Genes & Development 2008 Sep 15; 22(18):2479-84

  9. Huang GJ*, Bannerman D, Flint J. Chronic fluoxetine treatment alters behaviour, but not adult hippocampal neurogenesis, in BALB/cJ mice. Molecular Psychiatry 2008 Feb; 13, 119-121. 
  10. Keays DA, Tian G, Poirier KHuang GJ, Siebold C, Cleak J, Oliver PL, Fray M, Harvey RJ, Molnár Z,Piñon MC, Dear N, Valdar W, Brown SD, Davies KE, Rawlins JN, Cowan NJ, Nolan P, Chelly J, FlintJ. Mutations in α-tubulin cause hippocampal defects in mice and lissencephaly in humans. Cell 2007 Jan 12; 128(1):45-57
  11. Huang GJ, Herbert J. Stimulation of neurogenesis in the dentate gyrus of the adult rat by fluoxetine requires rhythmic change in corticosterone.Biological Psychiatry 2006 Apr 1; 59(7):619-24
  12. Huang GJ, Herbert J. Serotonin modulates the suppressive effects of corticosterone on proliferating progenitor cells in the dentate gyrus of the hippocampus in the adult rat. Neuropsychopharmacology 2005 Feb 30:231-241.