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Department of Biomedical Sciences




郁兆蘭(Chao-Lan Yu)

Chao-Lan Yu




Ph.D. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, USA



Office Tel

+886-3-211-8800 ext.3730

Lab Tel




Laboratory of cancer research


Cancer biology, Signal transduction and gene regulation

Lab & Research Interest

1. Oncogenes and tumor suppressors

2. Cancer metabolism and animal 2. Cancer metabolism and animal models

3. Molecular mechanisms of nuclear-mitochondri3. Molecular mechanisms of nuclear-mitochondrial crosstalk


Publications (since 2010):

1.  Vahedi S, Chueh F-Y, Chandran B, and Yu C-L. (2015). Lymphocyte-specific protein tyrosine kinase (Lck) interacts with CR6-interacting factor 1 (CRIF1) in mitochondria to repress oxidative phosphorylation. BMC Cancer 15:551.

2.  Vahedi S, Chueh F-Y, Dutta S, Chandran B, and Yu C-L. (2015). Nuclear lymphocyte-specific protein tyrosine kinase and its interaction with CR6-interacting factor 1 promote the survival of human leukemic T cells. Oncol. Rep34(1):43-50.

3.  Chueh F-Y, Cronk RJ, Alsuwaidan AN, Mallers TM, Jaiswal MK. Beaman KD, and Yu C-L. (2014). Mouse LSTRA leukemia as a model of human natural killer T cell and highly aggressive lymphoid malignancies. Leuk Lymphoma 55(3):706-708.

4.  Chueh F-Y and Yu C-L. (2012). Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells. Biochem. Biophys. Res. Commun. 426:242-246.

5.  Venkitachalam S, Chueh F-Y, and Yu C-L. (2011). Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene. Biochem. Biophys. Res. Commun. 417:1058-1062.

6.  Chueh F-Y, Leong K-F, Cronk RJ, Venkitachalam S, Pabich S, and Yu C-L. (2011). Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription. Cell. Signal. 23:1170-1178.

7.  Venkitachalam S, Chueh F-Y, Leong K-F, Pabich S, and Yu C-L. (2011).  Suppressor of cytokine signaling 1 interacts with lymphocyte-specific protein tyrosine kinase. Oncol. Rep. 25:677-683.

8.  Chueh F-Y, Leong K-F, and Yu C-L. (2010). Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells. Biochem. Biophys. Res. Commun. 402:778-783.

9.  Cooper JC, Shi M, Venkitachalam S, Chueh F-Y, and Yu C-L. (2010).  Enforced SOCS1 and SOCS3 expression attenuates Lck-mediated cellular transformation. Int. J. Oncol36:1201-1208.