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黃國正(Guo-Jen Huang)

黃國正 (Guo-Jen Huang)

職稱

Assistant Professor

最高學歷

Ph.D. University of Cambridge

E-mail

gjh30@mail.cgu.edu.tw

電話:

+886-3-211-8800 ext. 3802

傳真

+886-3-211-8700

實驗室

Functional Neuroscience Lab

專長

Genes and Neuroscience

研究方向及研究室特色

研究方向

人腦創造了許多高科技的產物,甚至建造了超級電腦,可是我們對自己腦是如何運作的卻依舊非常地模糊。揭開大腦是如何運作是一個令人著迷的問題,本實驗室目前的研究主題主要是專注在情緒焦慮,抗憂鬱藥物,認知學習記憶,生理運動,與腦神經老化方面。研究的方法主要是以小鼠的動物模式,來探討基因,腦神經細胞結構,生理賀爾蒙與動物行為,希望藉此來試著解開基因與神經的運作之謎。

目前實驗室的研究有以下幾個議題:

1) 個體成年後, 腦中增生的新神經細胞, 其生理上的功能為何?

2) 運動如何讓我們的腦神經細胞更健康,是透過如何機制?

3) 要如何讓年老的腦神經細胞年輕化?有哪些可能的候選因子?

4) 哪些基因在抗憂鬱或影響學習行為中扮演角色? 其背後的機轉為何?

Understanding how the brain works is among the most important challenges to 21st century science. One structure in the brain that has received considerable attention is the hippocampus, which is considered to play a part in learning and emotional regulation. Intriguingly, even in adults, new neurons continue to be born within the hippocampus. Scientists have assumed that the function of these newly born neurons in the adult hippocampus are linked to learning and emotion.  Unfortunately, there is still no consensus on what functions these new neurons perform.  It is important to unveil factors controlling the activity of the progenitors of these new neurons, the neuronal stem cells, and to investigate the functions of newly-formed neurons.  Our current work is focus on three projects:
1)  What are the functions of adult born hippocampal neurons?
2)  How does exercise benefit our brain, and by what molecular mechanism?
3)  How to make the aging brain younger?  What are the candidate factors?

論文與著作

Publications:  (*corresponding author)       
  1. Chang S, Bok P, Sun C-P, Edwards A, Huang G-J*. Neuropsin inactivation has protective effects against depressive-like behaviours and memory impairment induced by chronic stress. PLoS Genetics 2016; 12(10): e1006356

     
  2. Lin YS, Wang HY, Huang DF, Hsieh PF, Lin MY, Chou CH, Wu IJ, Huang GJ, Gau SS, Huang HS. Neuronal Splicing Regulator RBFOX3 (NeuN) Regulates Adult Hippocampal Neurogenesis and Synaptogenesis. PLoS One 2016 Oct 4;11(10):e0164164.

  3. Lin YT, Liu TY, Yang CY, Yu YL, Chen TC, Day YJ, Chang CC, Huang GJ, Chen JC. Chronic activation of NPFFR2 stimulates the stress-related depressive behaviors through HPA axis modulation. Psychoneuroendocrinology 2016 May 18;71:73-85. 

     
  4. Tarn WY, Kuo HC, Yu HI, Liu SW, Tseng CT, Dhananjaya D, Hung KY, Tu CC, Chang SH, Huang GJ, Chiu IM. RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression. Molecular Biology of the Cell 2016 May 15;27(10):1676-83.

     
  5. Cai N, Li Y, Chang S, Liang J, Lin C, Zhang X, Liang L, Hu J, Chan W, Kendler KS, Malinauskas T, Huang GJ, Li Q, Mott R, Flint J. Genetic control over mtDNA and Its relationship to major depressive disorder. Current Biology 2015 Dec 21;25(24):3170-77.

     
  6. Tsai CY, Tsai CY, Arnold S, Huang GJ*. Ablation of hippocampal neurogenesis in mice impairs the response to stress during the dark cycle. Nature Communications 2015 Sep 29;6:8373. doi: 10.1038/ncomms9373.

     
  7. Lee KC, Yu JF, Lee YS, Huang GJ, Chan HL, Lin IT, Chen JH. In vivo sodium MRI for mouse model of ischemic stroke at 7 T: Preliminary results.
    Journal of Medical and Biological Engineering 2015 Sep 30;35;643-650


     
  8. Cai N, Chang S, Li Y, Li Q, Hu J, Liang J, Song L, Kretzschmar W, Gan X, Nicod J, Rivera M, Deng H, Du B, Li K, Sang W, Gao J, Gao S, Ha B, Ho HY, Hu C, Hu J, Hu Z, Huang G,  Jiang G, Jiang T,Jin W, Li G, Li K, Li Y, Li Y, Li Y, Lin YT, Liu L, Liu T, Liu Y, Liu Y, Lu Y, Lv L, Meng H, Qian P, Sang H, Shen J, Shi J, Sun J, Tao M, Wang G, Wang G, Wang J, Wang L, Wang X, Wang X, Yang H,Yang L, Yin Y, Zhang J, Zhang K, Sun N, Zhang W, Zhang X, Zhang Z, Zhong H, Breen G, Wang J,Marchini J, Chen Y, Xu Q, Xu X, Mott R, Huang GJ, Kendler K, Flint J. Molecular signatures of major depression.
    Current Biology 2015 May 4;25(9):1146-56. (co-senior author)


     
  9. Huang GJ*, Edwards A, Tsai CY, Lee YS, Peng L, Era T, Hirabayashi Y, Tsai CY. Nishikawa S, Iwakura Y, Chen SJ, Flint J. Ectopic cerebellar cell migration causes maldevelopment of Purkinje cells and abnormal motor behaviour in Cxcr4 null mice. PLoS ONE 2014 Feb; 9(2): e86471

     
  10. Groves JO, Leslie I, Huang GJ, McHugh SB, Taylor A, Mott R, Munafò M, Bannerman DM, Flint J. Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model. PLoS Genetics 2013;9(9):e1003718

     
  11. Huang GJ*, Ben-David E, Tort Piella A, Edwards A, Flint J, Shifman S*. Neurogenomic evidence for a shared mechanism of the antidepressant effects of exercise and chronic fluoxetine in mice. PLoS ONE 2012 Apr 25; 7(4): e35901

     
  12. Edwards A, Treiber CD, Breuss M, Pidsley RHuang GJ, Cleak J, Oliver PL, Flint J. Keays DA. Cytoarchitectural disruption of the superior colliculus and an enlarged acoustic startle response in the Tuba1a mutant mouse. Neuroscience 2011 Nov 10; 195:191-200

  13. Huang GJ, Smith AL, Gray DH, Cosgrove C, Singer BH, Edwards A, Sims S, Parent JM, Johnsen A,Mott R, Mathis D, Klenerman P, Benoist C, Flint J. A genetic and functional relationship between T-cells and cellular proliferation in the adult hippocampus. PLoS Biology 2010 Dec 14; 8(12):e1000561

     
  14. Keays DA, Cleak J, Huang GJ, Edwards A, Braun A, Treiber C, Pidlsey R, Flint J. The role of Tuba1a in adult hippocampal neurogenesis and the formation of the dentate gyrus. Developmental Neuroscience 2010 Oct; 32(4):268-77

  15. Huang GJ, Shifman S, Johannesson M, Yalcin B, Valdar W, Taylor J, Mott R, Flint J. High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Research 2009 Jun; 19(6):1133-40

     
  16. Arnold S#, Huang GJ#( equal contribution), Cheung A, Era T, Nishikawa SI, Bikoff E, Molnar E, Robertson E, Groszer M. The T-box transcription factor Tbr2/Eomes regulates neurogenesis in the cortical subventricular zone. Genes & Development 2008 Sep 15; 22(18):2479-84

     
  17. Huang GJ*, Bannerman D, Flint J. Chronic fluoxetine treatment alters behaviour, but not adult hippocampal neurogenesis, in BALB/cJ mice. Molecular Psychiatry 2008 Feb; 13, 119-121. 

     
  18. Keays DA, Tian G, Poirier K, Huang GJ, Siebold C, Cleak J, Oliver PL, Fray M, Harvey RJ, Molnár Z,Piñon MC, Dear N, Valdar W, Brown SD, Davies KE, Rawlins JN, Cowan NJ, Nolan P, Chelly J, FlintJ. Mutations in α-tubulin cause hippocampal defects in mice and lissencephaly in humans. Cell 2007 Jan 12; 128(1):45-57

     
  19. Huang GJ, Herbert J. Stimulation of neurogenesis in the dentate gyrus of the adult rat by fluoxetine requires rhythmic change in corticosterone.
    Biological Psychiatry 2006 Apr 1; 59(7):619-24


     
  20. Huang GJ*,  Herbert J. The role of 5-HT1A receptors in the proliferation and survival of progenitor cells in the dentate gyrus of the adult hippocampus and their regulation by corticoids. Neuroscience 2005 Aug 135(3):803-13

     
  21. Huang GJ, Herbert J. Serotonin modulates the suppressive effects of corticosterone on proliferating progenitor cells in the dentate gyrus of the hippocampus in the adult rat. Neuropsychopharmacology 2005 Feb 30:231-241.