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Department of Biomedical Sciences

 

 

 
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Scott C. Schuyler

Scott C. Schuyler

Position

Assistant Professor

Education

Ph.D. in Cell and Developmental Biology, Harvard University, USA

E-mail

schuyler@mail.cgu.edu.tw

Office Tel

+886-3-211-8800 ext. 3596

Fax

+886-3-211-8700

Laboratory

https://scs03596.wixsite.com/scslab

Speciality

Cell Biology, Cell Cycle, Protein Biochemistry, Yeast Genetics

Lab & Research Interest

Mitotic Spindle Checkpoint, Chromosome Segregation and Cell Cycle Regulation

The mitotic spindle checkpoint prevents chromosome loss. I want to understand how this checkpoint regulates chromosome segregation during eukaryotic cell division, primarily by studying how the spindle checkpoint inhibits the cell cycle regulator the Anaphase-Promoting Complex (APC).  Yeast genetics, cell biology, and biochemistry in combination are powerful tools for exploring the molecular roles of protein complexes. In the lab, I use my training in these fields to develop biochemical, cell biological and genetic approaches to ask how the mitotic spindle checkpoint functions to inhibit APC.

Publications


  1. Wu SY, Kuan VJ, Tzeng YW, Schuyler SC, Juang YL. (2016) The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase. Fungal Genet Biol. 2016 Mar 16;91:6-19.
  2. Wu CC1, Wu HJ, Wang CH, Lin CH, Hsu SC, Chen YR, Hsiao M, Schuyler SC, Lu FL, Ma N, Lu J. (2015) Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells. Cell Cycle. 2015 Apr 15;14(8):1207-17.
  3. Gopinath RK, You ST, Chien KY, Swamy KBS, Yu JS, Schuyler SC and Leu JY. (2014) The Hsp90-dependent proteome is conserved and enriched for hub proteins with high levels of protein-protein connectivity. Genome Biology and Evolution. Oct 13;6(10):2851-65.
  4. Hsuan L, Ma C-P, Chen Y-T,Schuyler SC, Chang K-P and Tan BC. (2014)  Functional Impact of RNA Editing and ADARs on Regulation of Gene Expression: Perspectives from Deep Sequencing Studies. Cell & Bioscience. Aug 19;4:44.
  5. Liu YC, Kao YT, Huang WK, Lin KY, Wu SC, Hsu SC, Schuyler SC, Li LY, Leigh Lu F, Lu J. (2014) CCL5/RANTES is important for inducing osteogenesis of human mesenchymal stem cells and is regulated by dexamethasone. Biosci Trends. Jun;8(3):138-43.
  6. Wang CH, Ma N, Lin YT, Wu CC, Wu HJ, Yu CC, Hsiao M, Lu FL, Schuyler SC, Lu J. (2013) Array-based high-throughput screening in mouse embryonic stem cells with shRNAs. Curr Protoc Stem Cell Biol. Sep 20;26:Unit 5C.3.
  7. Huang H-N, Chen S-Y, Hwang S-M, Su M-W, Mai W, Wang H-W, Cheng W-C, Schuyler SC, Ma N, Lu FL, Lu J.  (2013) miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation.  Stem Cell Res. Dec 3;12(2):338-353.
  8. Lu FL, Yu C-C, Chiu H-H, Liu HE, Chen S-Y, Lin S, Goh T-Y, Hsu H-C, Chien C-H, Wu H-C, Chen M-S, Schuyler SC, Hsieh W-S, Wu M-H, Lu J.  (2013) Sonic hedgehog antagonists induce cell death in acute myeloid leukemia cells in the presence of lipopolysaccharides, tumor necrosis factor-α, or interferons.  Invest. New Drug.  Aug 31(4):823-32.
  9. Schuyler SC, Wu Y-F, Kuan VJ-W.  (2012) The Mad1-Mad2 balancing act - a damaged spindle checkpoint in chromosome instability and cancer.  J Cell Sci. Sep 15;125(Pt 18):4197-4206.
  10. Tzeng Y-W, Huang JN, Schuyler SC, Wu C-H, Juang Y-L.  (2011) Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase.  Fungal Genet Biol. Oct;48(10):966-78.
  11. Barnhart EL, Dorer RK, Murray AW, Schuyler SC*.  (2011) Reduced Mad2 expression keeps relaxed kinetochores from arresting budding yeast in mitosis.  Mol Biol Cell, Jul;22(14):2448-2457.
  12. Wu Y-P, Chang C-M, Hung C-Y, Tsai M-C, Schuyler SC, Wang RY-L*.  (2011) Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity.  Virol J. 8:128.  Erratum in: Virol J. 8:338.