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Department of Biomedical Sciences

 

 

 
:::

周成功(Chen-Kung Chou)

Chen-Kung Chou

Position

Chair Professor

Education

Ph.D. in Molecular Biology, Albert Einstein College of Medicine, USA

E-mail

ckchou@mail.cgu.edu.tw

Office Tel

+886-3-211-8800 ext.3354

Fax

+886-3-211-8700

Laboratory

Laboratory of Aging and Cancer Research

Spciality

Biochemistry, Molecular Biology, Signal Transduction

Publications

Publications:

  1. Liu MA, Huang AM, Chou CKLiaw GJ, Wu CW.(2001)   Utilization of Drosophila eye to probe the functions of two mammalian serine/threonine kinases, Snk and HsHPK. J Biomed Sci. 8:270-7.
  2. Tsao N, Luh TY, Chou CK, Wu JJ, Lin YS, Lei HY. (2001)  Inhibition of group A streptococcus infection by carboxyfullerene. Antimicrob Agents Chemother. 45: 1788-93. 
  3. Tu LC, Chou CK, Chen HC, Yeh SF.(2001)   Protein kinase C-mediated tyrosine phosphorylation of paxillin and focal adhesion kinase requires cytoskeletal integrity and is uncoupled to mitogen-activated protein kinase activation in human hepatoma cells. J Biomed Sci. 8:184-90. SCI, NSC88-2315-B-010-002-MH
  4. Lin AM, Fang SF, Lin SZ, Chou CK, Luh TY, Ho LT. (2002) Local carboxyfullerene protects cortical infarction in rat brain. Neurosci Res. 43:317-21.
  5. Tsao N, Luh TY, Chou CKChang TY, Wu JJ, Liu CC, Lei HY.(2002)   In vitro action of carboxyfullerene. J Antimicrob Chemother. 49:641-9.
  6. Chiu AW, Huang YL, Huan SK, Wang YC, Ju JP, Chen MF, Chou CK(2002)    Potential molecular marker for detecting transitional cell carcinoma. Urology. 60:181-5.
  7. Tsou AP, Yang CW, Huang CY, Yu CT, Lee YC, Chang CW, Chen BR, Chung YF, Fann MJ, Chi CW, Chiu JH, Chou CK*. (2003) Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. Oncogene. 22: 298-307.  SCI, NSC91-2323-B075-001,
  8. Chien CY, Liu WK, Chou CKSu JY. (2003) The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation. FEBS Lett. 543:55-60. SCI, NSC-90-2320-B-010-057, 89-B-FA22-2-4, NSC-90-2320-B-010-081, NHRI-EX90-9001BL
  9. Liu WK, Chien CY, Chou CKSu JY.(2003) An LKB1-Interacting Protein Negatively Regulates TNFalpha-Induced NF-kappaB Activation. J Biomed Sci. 10: 242-52.
  10. Tsou AP, Chuang YC, Su JY, Yang CW, Liao YL, Liu WK, Chiu JH, Chou CK*. (2003)  Overexpression of a novel imprinted gene, PEG10, in human hepatocellular carcinoma and in regenerating mouse livers. J Biomed Sci. 10:625-35. SCI, NHRI-EX91-9001BL, 89-B-FA22-2-4
  11. Lin YL, Shiao MS, Mettling C, Chou CK(2003) Cholesterol requirement of hepatitis B surface antigen (HBsAg) secretion. Virology. 314:253-60.
  12. Huang HL, Fang LW, Lu SP, Chou CKLuh TY, Lai MZ. (2003)  DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation. Oncogene. 22:8168-77.
  13. Lee CH, Ni YH, Chen CC, Chou CK, Chang FH. (2003) Synergistic effect of polyethylenimine and cationic liposomes in nucleic acid delivery to human cancer cells. Biochim Biophys Acta. 1611:55-62.
  14. Liu WK, Yen PF, Chien CY, Fann MJ, Su JY, Chou CK*. (2004) The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKγ to block activation of the transcription factor NF-κB and potentiate apoptosis. Biochem. J. 378:867-76
  15. Wang YH, Lee EJ, Wu CM, Luh TY, Chou CK, Lei HY. (2004)Inhibition of middle cerebral artery occlusion-induced focal cerebral ischemia by carboxyfullerene. J. Drug Del. Sci. Tech. 14:45-9.
  16. Tu LC, Chou CKChen CY, Chang YT, Shen YC, Yeh SF. (2004)Characterization of the cytotoxic mechanism of Mana-Hox, an analog of manzamine alkaloids. Biochim Biophys Acta. 1672:148-56.
  17. Wang JY, Chiu JH, Tsai TH, Tsou AP, Hu CP, Chi CW, Yeh SF, Lui WY, Wu CW, Chou CK. (2005) Gene expression profiling predicts liver responses to a herbal remedy after partial hepatectomy in mice. Int J Mol Med.  Aug;16(2):221-31.
  18. Li Y, Fu L, Yeo H, Zhu JL, Chou CK, Kou YH, Yeh SF, Gullen E, Austin D, Cheng YC. (2005)Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative. Antivir Chem Chemother.  16(3):193-201.
  19. Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY. (2005)Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol Cell Biol.  Jul;25(14):5789-800.
  20. Yang CW, Su JY, Tsou AP, Chau GY, Liu HL, Chen CH, Chien CY, Chou CK*. (2005)Integrative genomics based identification of potential human hepatocarcinogenesis-associated cell cycle regulators: RHAMM as an example. Biochem Biophys Res Commun.  May 6;330(2):489-97.
  21. Wu JC, Chen TY, Yu CT, Tsai SJ, Hsu JM, Tang MJ, Chou CK, Lin WJ, Yuan CJ, Huang CY. (2005) Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. J Biol Chem.  Mar 11;280(10):9013-22.
  22. Chang Y, Lee TC, Li JC, Lai TL, Chua HH, Chen CL, Doong SL, Chou CKSheen TS, Tsai CH. (2005) Differential expression of osteoblast-specific factor 2 and polymeric immunoglobulin receptor genes in nasopharyngeal carcinoma. Head & Neck. October;27(10):873-82.
  23. Yang CW, Hsiao CF, and Chou CK(2005)Evaluation of Experimental Designs for Two-Color cDNA Microarrays J. of Computational Biology.  November 12(9):1202-20
  24. Li CC, Chou CK, Wang MH, Tsai TF. (2006)Overexpression of ABIN-2, a negative regulator of NF-kB, delays liver regeneration in the ABIN-2 transgenic mice. Biochem Biophys Res Commun.  Mar 31;342(1):300-9. [領域: Biochemistry & Molecular Biology,  IF:2.904,   排名(Ranking):103/261]
  25. Wu BK, Li CC, Chen HJ, Chang JL, Jeng KS, Chou CKHsu MT, Tsai TF. (2006)Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B virus X protein transgenic mice. Biochem Biophys Res Commun.  2006 Feb 17;340(3):916-28.  [領域: Biochemistry & Molecular Biology,  IF:2.904,   排名(Ranking):103/261]
  26. Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK*, Chen CM. (2006) Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. Exp Cell Res.   2006 Jan 18;  in press[Epub ahead of print]  [領域: cell Biology,  IF:4.007,   排名(Ranking):47/154],  通訊作者